QBI - Seminar

The Human C2H2 Zinc Finger Proteins Are Important Participants In RNA Biology

QBI presents a seminar with Jack Greenblatt, Professor in the Donnelly Centre and the Department of Molecular Genetics in the Faculty of Medicine at the University of Toronto.

Dr. Greenblatt obtained a B.Sc. in Physics from McGill University in 1973 and a Ph.D. in Biophysics with Walter Gilbert at Harvard University in 1973, where his research focused on gene regulation in E. coli. After post-doctoral training at the University of Geneva, where he also worked as a Research Associate, and the Pasteur Institute in Paris, he went to the University of Toronto, where he is currently a University Professor. His research has focused primarily on mechanisms that regulate transcription, as well as the importance of protein-protein interactions for that regulation, first in bacteria, then in yeast, and, most recently, in human cells.

There are more than 700 human C2H2 zinc finger proteins (C2H2-ZFPs), and they generally recognize specific sequences in DNA. Although they constitute nearly half the human DNA-binding proteins, relatively little is known about their biological functions. They interact with a wide variety of other human proteins, and they generally interact with RNA, as well as DNA, suggesting that they might have diverse roles in RNA biology. Examples will be provided of the involvement of RNA-binding by various C2H2-ZFPs in the regulation of mRNA splicing, mRNA modification, mRNA export, mRNA 3’-end formation, and chromosome conformation.

Talk Title: The Human C2H2 Zinc Finger Proteins Are Important Participants In RNA Biology

Host: Nevan Krogan 

Share event by Email

Share event to your friends by email.