Co-organized by Drs. Kathy Giacomini, Nevan Krogan, Aldema Sas-Chen, and Ron Shamir, the Quantitative Biosciences Institute (QBI) at the University of California, San Francisco, the Edmond J. Safra Center for Bioinformatics at Tel Aviv University (TAU), and the BLAVATNIC CENTER for Drug Discovery at TAU present the second "QBI/UCSF-TAU Symposium on Computational Biology and Drug Discovery."

QBI seeks transformative results in biomedicine by supporting fundamental quantitative research in the biological sciences. ​The Edmond J. Safra Center for Bioinformatics promotes TAU as a leading force in the field of bioinformatics towards the development of novel drugs and biomedical technologies that will improve human health. The BLAVATNIK CENTER for Drug Discovery aims to turn excellent multidisciplinary science into therapeutics leads. The 2023 ​symposium aims to continue facilitating collaborative relationships between scientists from the participating institutions. 

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AGENDA

DAY 1 - Tuesday, May 16

8:30 AM - Registration and Coffee 

9:00 AM - Opening Remarks by Nevan Krogan, Kathy Giacomini, Ron Shamir, and Aldema Sas-Chen

MORNING SESSION - Chair: Ron Shamir

9:15 AM - Ehud Gazit, TAU | Professor & Endowed Chair, Molecular Microbiology and Biotechnology; Founding Director, BLAVATNIK CENTER for Drug Discovery

"Peptide and metabolite self-assembly: Physiology, pathology and nanotechnology"

9:30 AM - Kathy Giacomini, QBI/UCSF | Dean, School of Pharmacy; Co-Director UCSF-Stanford Center of Excellence in Regulatory Sciences and Innovation; Professor, Bioengineering and Therapeutic Sciences

"The UCSF-Stanford Center of Excellence In Regulatory Science: Advancing Drug Discovery'

9:45 AM - Noam Shomron, TAU | Professor, Cell and Developmental Biology

"Applied Genomics: what DNA and RNA can tell us"

10:00 AM - Michelle Arkin, QBI/UCSF | Professor, Pharmaceutical Chemistry; Co-Director, Small Molecule Discovery Center

"Structure-guided design of covalent probes and drug leads for hard targets"

10:15-10:35 AM - BREAK

10:35 AM - Margaux Pinney, QBI/UCSF | Assistant Researcher, Biochemistry and Biophysics; Sandler Faculty Fellow

"Leveraging High-Throughput Microfluidic Technologies to Quantify Drug Resistance Landscapes"

10:50 AM - Vered Padler-Karavani, TAU | Associate Professor, Cell Research and Immunology

"Targeting the sweet spot of human diseases"

11:05 AM - James Fraser, QBI/UCSF | Professor, Bioengineering

"Drugging Macrodomains"

11:20 AM - Ignacia Echeverria, QBI/UCSF | Assistant Professor, Cellular Molecular Pharmacology

"Structure modeling of related protein complexes in multiple conformational or compositional states"

12:00-1:30 PM - LUNCH

AFTERNOON SESSION - Chair: Aldema Sas-Chen

1:30 PM - Tamir Tuller, TAU | Professor, Bio-Medical Engineering; Director, Laboratory of Computational Systems and Synthetic Biology

"Computational modelling of gene expression: intro and medical applications"

1:45 PM - Marina Sirota, QBI/UCSF | Associate Professor, Pediatrics

"Leveraging Molecular and Clinical Data for Drug Discovery in the Era of Precision Medicine"

2:00 PM - Martin Kupiec, TAU | Professor, Molecular Microbiology and Biotechnology; President, Genetic Society of Israel

"Systematic analysis of the mechanisms that maintain telomere length"

2:15 PM - Elhanan Borenstein, TAU | Professor, School of Computer Science; Professor, Sackler Faculty of Medicine; Head, Edmond J. Safra Center for Bioinformatics

"Studying the gut microbiome interaction with metabolites, diet, and drugs"

2:30-2:50 PM - BREAK

2:50 PM - Nir Ben-Tal, TAU | Professor, Biochemistry Molecular Biology

"Anti-influenza A virus drug discovery"

3:05 PM - Tanja Kortemme, QBI/UCSF | Professor, Bioengineering

"New conformations and functions of de novo designed proteins"

3:20 PM - Yoni Haitin, TAU | Assistant Professor, Physiology Pharmacology

"Structure-based identification of novel geranylgeranyl diphosphate synthase inhibitors for multiple myeloma treatment"

3:35 PM - Ron Shamir, TAU | Sackler Professor; Bionformatics

"Analysis of disease using multiomic data"

3:50 PM -  Closing Remarks

DAY 2 - Wednesday, May 17

8:30 AM - Registration and Coffee 

MORNING SESSION - Chair: Nevan Krogan

9:00 AM - Nadav Ahituv, QBI/UCSF | Professor, Bioengineering; Director, UCSF Institute for Human Genetics

"Functional characterization and therapeutic targeting of gene regulatory elements"

9:15 AM - Rina Rosin-Arbesfeld, TAU | Professor, Department of Clinical Microbiology and Immunology; Vice Dean, Faculty of Medicine

"Novel therapeutic strategies for treating diseases caused by nonsense mutations"

9:30 AM - Ran Elkon, TAU | Associate Professor, Human Molecular Genetics Biochemistry

"Enhancing early detection of breast cancer using polygenic risk scores"

9:45-10:10 AM - BREAK

10:10 AM - Brian Shoichet, QBI/UCSF | Professor, Pharmaceutical Chemistry

"Following the Rabbit into Chemical Space"

10:25 AM - Aldema Sas-Chen, TAU | Assistant Professor/Senior Lecturer, Biomedicine and Cancer Research

"When the heat is on – turn up the AC(4C): roles for dynamic acetylation in thermostabilization of RNA"

10:40 AM - Tzachi Hagai, TAU | Senior Lecturer, Molecular Cell Biology & Biotechnology

"The Evolutionary Paradox of Host-Virus interactions"

10:55 AM - Closing Remarks