Organized by Drs. Walter Kolch of the University College Dublin (UCD) and Nevan Krogan of the Quantitative Biosciences Institute at the University of California, San Francisco (UCSF), the inaugural QBI/SBI-UCD Symposium on Molecular Networks of Cancer and Other Diseases will be held virtually on October 29 - 30, 2020 from 8:00 - 10:45 AM PDT.

The Quantitative Biosciences Institute (QBI) seeks transformative results in biomedicine by supporting fundamental quantitative research in the biological sciences. Systems Biology Ireland (SBI) at University College Dublin (UCD) specializes in the analyses and modeling of cellular signal transduction networks with a particular focus on developing new diagnostics and treatment strategies for cancer and inflammatory diseases. 

The 2020 QBI/SBI Symposium on Molecular Networks of Cancer and Other Diseases aims to facilitate collaborative relationships between scientists from both the US and Ireland. QBI and UCD recently signed a 5-year MOU to reinforce the links between scientists in San Francisco and Dublin, and enhance their collaborative ability to strengthen scientific research and innovation. Through this agreement, scientists will work together to identify opportunities to promote cooperative biosciences research and training activities.

Please click the link below to join the webinar:

https://ucsf.zoom.us/j/99271933485?pwd=NWIrZTc1SE1uUGh4RGZNVDkzTlJ3UT09

Webinar ID: 992 7193 3485

Passcode: 016862

Day 1: October 29, 2020

8:00 PST, 3:00 GMT Opening Remarks by Nevan Krogan, QBI/UCSF, Walter Kolch, SBI/UCD, Aoife Ryan, Science Foundation Ireland 

8:10 PST, 3:10 GMT Donal Brennan, SBI/UCD, Professor, Gynaecological Oncology; Consultant Gynaecological Oncologist, Mater Misericordiae University Hospital

“Epithelial Ovarian Cancer and Systems Biology - a challenge and an opportunity”

8:25 PST, 3:25 GMT Nevan Krogan, QBI/UCSF, Professor, Cellular Molecular Pharmacology at UCSF; Director, Quantitative Biosciences Institute at UCSF; Investigator, Gladstone Institute

“Cancer Cell Map Initiative: Interpreting cancer genomes with protein protein interaction maps”

8:40 PST, 3:40 GMT Maria Prencipe, UCD, SFI Starting Investigator, School of Biomolecular and Biomedical Research, Cancer Biology and Therapeutics Lab, Conway Institute of Biomolecular and Biomedical Research 

“Targeting co-regulators of hormone-receptors as a novel therapeutic approach for prostate and breast cancer'.”

8:55 PST, 3:55 GMT Kathy Giacomini, QBI/UCSF, Professor, Dept of Bioengineering; Co-Director, UCSF-Stanford Center of Excellence in Regulatory Sciences and Innovation

"Genomics of the Solute Carrier Superfamily: Discovering new drug targets”

9:10-9:15 PST, 4:10-4:15 CEST Break

9:15 PST, 4:15 GMT William Gallagher, UCD, Director, UCD Conway Institute; Deputy Director, Precision Oncology Ireland; Full Professor, Cancer Biology

“Translating Breast Cancer Transcriptional Signatures into Clinically Relevant Assays: The OncoMasTR Story'”

9:30 PST, 4:30 GMT Balyn Zaro, QBI/UCSF, Assistant Professor, Dept of Pharmaceutical Chemistry

“Connecting Infection and Cancer: Bacterial Mimicry of a Mammalian ‘Don’t Eat Me’ Signal”

9:45 PST, 4:45 GMT Susan Quinn, UCD, Associate Professor, Senior Lecturer in Physical Chemistry 

“Towards photoactive molecular and nanoparticle based therapeutics" ”

10:00 PST, 5:00 GMT Trever Bivona, QBI/UCSF, Professor, Dept of Medicine

"Molecular networks underlying lung cancer evolution during therapy”

10:15 PST, 5:15 GMT Oleksii Rukhlenko, SBI/UCD, Former Marie Sklodowska Curie Postdoctoral Fellow

"Targeting oncogenic RAS with next-generation modeling"

10:30 PST, 5:30 GMT Walter Kolch, Director, Systems Biology Ireland & Conway Institute

“From networks to cancer diagnosis and treatments”

Day 2: October 30, 2020

8:00 PST, 3:00 GMT Intro Remarks

8:05 PST, 3:05 GMT Christina Kiel, SBI/UCD, SFI Principal Investigator; Group Leader, Systems Biology Ireland and UCD Charles Institute of Dermatology, UCD School of Medicine

“Computational model of metabolism predicts Ras mutant phenotypes”

8:20 PST, 3:20 GMT Michelle Arkin, QBI/UCSF, Professor, Dept of Pharmaceutical Chemistry; Co-director, Small Molecule Discovery Center

“Chemical biology of protein-protein interaction networks”

8:35 PST, 3:35 GMT Colm Ryan, SBI/UCD, Assistant Professor, School of Computer Science; Group Leader, Systems Biology Ireland 

“Comprehensive prediction of synthetic lethality between paralog pairs in cancer”

8:50 PST, 3:50 GMT Kevan Shokat, QBI/UCSF, Professor and Vice-Chair, Dept of Cellular and Molecular Pharmacology at UCSF; Professor, Dept of Chemistry at UC Berkeley; Investigator, Howard Hughes Medical Institute

“Drug Discovery from Oncology to Host-directed anti-Virals”

9:05-9:15 PST, 4:05-4:15 CEST Break Featuring a Musical Performance by Bob Stroud & The Jailbreakers 

9:15 PST, 4:15 GMT Jonathan Bond, SBI/UCD, Childhood leukemia research at SBI and Children's Health Ireland

“Childhood leukemia research at Systems Biology Ireland"

9:30 PST, 4:30 GMT Charles Craik, QBI/UCSF, Professor, Dept of Pharmaceutical Chemistry; Co-Leader, Experimental Therapeutics, Helen Diller Family Comprehensive Cancer Center

“Targeting an Intracellular Oncoprotein in MHC I for Immunotherapy”

9:45 PST, 4:45 GMT Ariane Watson, SBI/UCD, Former Marie Sklodowska Curie Postdoctoral Fellow

“Loss of SWI/SNF promotes resistance to BRAF inhibition in BRAFV600E mutant melanomas”

10:00 PST, 5:00 GMT Danielle Swaney, QBI/UCSF, Assistant Professor, Dept of Cellular Molecular Pharmacology

“A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity”

10:15 PST, 5:15 GMT Antoinette Perry, UCD, Assistant Professor of Cell Biology and Genetics; Vice Principal for Equality, Diversity and Inclusion, UCD College of Science; UCD Conway Fellow 

"Translational Prostate Cancer Epigenomics via Liquid Biopsies"

10:30 PST, 5:30 GMT 

Alan Ashworth, QBI/UCSF, Professor, Dept of Medicine; Senior Vice President for Cancer Services; President, UCSF Helen Diller Family Comprehensive Cancer Center

“Synthetic Lethal Approaches to Cancer Therapy”

10:45 PST, 5:45 GMT End of Symposium Day 2

Speaker List:

Michelle Arkin, QBI|UCSF

Alan Ashworth, QBI|UCSF

Trever Bivona, QBI|UCSF

Donal Brennan, SBI|UCD

Jonathan Bond, SBI|UCD

Charles Craik, QBI|UCSF

Liam Gallagher, UCD

Kathy Giacomini, QBI|UCSF

Christina Kiel, SBI|UCD

Antoinette Perry, UCD

Maria Prencipe, UCD

Susan Quinn, UCD

Oleksii Ruhklenko, SBI|UCD

Colm Ryan, SBI|UCD

Kevan Shokat, QBI|UCSF

Danielle Swaney, QBI|UCSF

Ariane Watson, SBI|UCD

Balyn Zaro, QBI|UCSF