Co-organized by Drs. Christian Freund, Natalia Jura, and Nevan Krogan, the Quantitative Biosciences Institute (QBI) and Freie Universität Berlin (FUB) present the Integrative Mechanistic Biology Meeting to be held in San Francisco from June 4-5, 2024.

QBI seeks transformative results in biomedicine by supporting fundamental quantitative research in the biological sciences through significant collaborative efforts. The department of Biology, Chemistry & Pharmacy at FUB seeks to translate the insights from atomistic descriptions of macromolecular structure to fundamental questions in biology, chemistry and medicine. In support of these missions, the 2024 joint symposium will focus on further advancing collaborative potential between scientists from both institutions. 

AGENDA:

DAY 1 – JUNE 4
8:30 AM – Registration & Light Breakfast

9:00 AM – Opening Remarks by:
Beate Antonich, Senior Advisor for Science and Technology for the Consulate General of Germany in San Francisco
Christian Freund, Professor of Protein Biochemistry at FUB
Natalia Jura, Professor in the Department of Cellular and Molecular Pharmacology at UCSF

SESSION 1:

9:15 AM – Kliment Verba, QBI - UCSF | Visualizing Near Membrane Signalling Assemblies with CryoEM

9:35 AM – Volker Haucke, FMP | Lipid Control of Membrane Dynamics in Health & Disease

9:55 AM – Natalia Jura, QBI - UCSF | Control Mechanisms of Receptor Tyrosine Kinase Signaling

10:15 AM – Francesca Bottanelli, FU Berlin | Unraveling the Inner Secrets of Cells with Live-cell Super-resolution Microscopy

10:35 AM – Break

SESSION 2:

10:50 AM – Dorothea Fiedler, FMP | Beyond Phosphorylation - Protein Pyrophosphorylation and More?

11:10 AM – Jim Wells, QBI - UCSF | Attacking the Cancer Surfaceome

11:30 AM – Eva Absmeier, FU Berlin | mRNA Translation and Decay

11:50 AM – Markus Ralser, Charité | Large-scale Proteomics to Study Cellular Metabolism and to Advance Drug Discovery

12:10 PM – Lunch

SESSION 3:

1:10 PM – Panel Discussion moderated by Michelle Arkin | AI Based Methods in Mechanistic Biology, featuring:
David Agard, QBI - UCSF
Cecilia Clementi, FU Berlin
Markus Ralser, Charité
Kliment Verba, QBI - UCSF

1:40 PM – Michelle Arkin, QBI - UCSF | Designing Function-selective Modulators for Multifunctional Proteins

2:00 PM – Christian Freund, FU Berlin | Dynamic Aspects of Antigen Presentation and T-Cell Activation

2:20 PM – Break

SESSION 4:

2:40 PM – Jeannette Tenthorey, QBI - UCSF | Evolving Difficult de novo Antiviral Functions via Indel Mutagenesis

3:00 PM – Einar Krogsaeter, QBI - UCSF | Leveraging Proteomics to Understand Disease Pathology

3:20 PM – Catera Wilder, QBI - UCSF | Dynamic Control of Signaling Networks: Uncovering Specificity in Cellular Responses

3:40 PM – Break

SESSION 5:

4:00 PM – Aashish Manglik, QBI - UCSF | Cracking Codes in Cellular Communication

4:20 PM – Stephan Sigrist, FU Berlin | An Extended Rab3-GAP Controlling Active Zone Structure & Function

4:40 PM – David Agard, QBI - UCSF | The Promise of CryoET for Discovery Structural Cell Biology
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DAY 2 – JUNE 5
8:30 AM – Registration & Light Breakfast

SESSION 6:

9:00 AM – Allison Williams, QBI - UCSF | Penetrating Bacterial Defenses by Targeting Cell Wall-Degrading Enzyme Machine

9:20 AM – Oliver Daumke, MDC | Structural Studies on Mitochondrial Membrane Remodeling

9:50 AM – Dan Minor, QBI - UCSF | Some Assembly Required: A First Structural View of Ion Channel Biogenesis

10:10 AM – Cecilia Clementi, FU Berlin | Navigating Protein Landscapes With A Machine-learned Transferable Coarse-grained Model

10:30 AM – Daniel Southworth, QBI - UCSF | Targeting Structural Conformations of Tau Filaments in Neurodegenerative Disease

10:50 AM – Break

SESSION 7:

11:10 AM – Fan Liu, FMP | Developing Structural Interactomics and Its Application in Cell Biology

11:30 AM – Bill DeGrado, QBI - UCSF | De Novo Protein Design

11:50 AM – Zahar Barth-Manzoori & Diego Rivas | Funding Opportunities and Exchange Between SF and Berlin Areas

12:05 PM – Closing Remarks