QBI presents the inaugural QBI Bay Area Symposium on Chemical Biology on September 26-27, 2022, organized by Drs. Jim Wells, Kevan Shokat, Jason Gestwicki, Chris Chang, and Carolyn Bertozzi. Under the leadership of Dr. Nevan Krogan, the Quantitative Biosciences Institute (QBI) seeks transformative results in biomedicine by supporting fundamental quantitative research in the biological sciences.

In support of this mission, the meeting will focus on the latest cutting edge Chemical Biology research to address unmet biological problems with new technologies and targets from top scientists in the Bay Area.

The meeting will provide opportunities for scientists at all career stages, including faculty, undergrad, graduate and postdoc levels to present their research in dynamic talks, Twitter interviews, panel discussions, poster sessions and mixers.

*All attendees must follow up to date UCSF COVID policies. Protocols for the event are outlined at the bottom of this page. UCSF's up to date policies can also be found here.

View photos from the event

Confirmed Speakers:

Patrick Baeuerle, MPM Capital

Matt Bogyo, Stanford University

Paul Carter, Genentech

Jamie Cate, University of California, Berkeley

Chris Chang, University of California, Berkeley

Andrew Chan, Genentech

Michelle Chang, University of California, Berkeley

James Chen, Stanford University

Charly Craik, University of California, San Francisco

Laura Dassama, Stanford University

Bill DeGrado, University of California, San Francisco

Ray Deshaies, Amgen

Jennifer Doudna, University of California, Berkeley

Pam England, University of California, San Francisco

Polly Fordyce, Stanford University

Matt Francis, University of California, Berkeley

Danica Fujimori, University of California, San Francisco

Zev Gartner, University of California, San Francisco

Jason Gestwicki, University of California, San Francisco

Nathanael Gray, Stanford University

Charles Homcy, BridgeBio

Natalia Jura, University of California, San Francisco

Peter Kim, Stanford University

Eric Kool, Stanford University

Misty Kuhn, San Francisco State University

Lingyin Li, Stanford University

John Link, Gilead Sciences

Shiva Malek, Novartis

Michael Marletta, University of California, Berkeley

Nicole Martinez, Stanford University

Evan Miller, University of California, Berkeley

Dan Nomura, University of California, Berkeley

Adam Renslo, University of California, San Francisco

Arnon Rosenthal, Alector

Alanna Schepartz, University of California, Berkeley

Ian Seiple, University of California, San Francisco

Jason Sello, University of California, San Francisco

Kevan Shokat, University of California, San Francisco

Xiaokun Shu, University of California, San Francisco

Jack Taunton, University of California, San Francisco

Alice Ting, Stanford University

Lei Wang, University of California, San Francisco

Jim Wells, University of California, San Francisco

Allison Williams, University of California, San Francisco

Balyn Zaro, University of California, San Francisco

Wenjun Zhang, University of California, Berkeley

SPEAKER QUESTIONS

To ask questions during a session:

-Go to https://pigeonhole.at/2627

OR scan the QR code below with phone camera and click the link that pops up

-Enter the Q&A

-Create a profile by clicking profile in the top right and add your name

-Enter your question and make sure to indicate which speaker you are addressing.

AGENDA

Day 1 - September 26th

8:00 AM: Registration & Breakfast

9:00-9:10 AM: Symposium begins: Welcome from organizers 

Session 1 - 9:10-10:25 AM: Chemical Biology of Metals | Chaired by: Nathanael Gray

9:10 AM Chris Chang | Transition Metal Signaling and Metalloallostery: Bioinorganic Chemistry Beyond Active Site

9:20 AM  Michelle Chang | Synthetic biology approaches to new chemistry

9:30 AM  Adam Renslo | Chemical tools to study labile iron in cells and animals

9:40 AM  Laura Dassama | Chemical biology tools for hematologic disorders

9:50 AM  Michael Marletta | Probing for novel therapeutic targets in human and plant disease

10:00 AM  Jim Wells | Proximity labeling for high resolution protein neighborhoods

10:10 AM  15 min questions: https://pigeonhole.at/2627

10:25-10:45 AM: Break Coffee Tea Cookies

Session 2 - 10:45-12:00 PM: Chemoproteomics and Covalent Therapeutics | Chaired by: Danica Fujimori

10:45 AM  Dan Nomura | Reimagining Druggability using Chemoproteomic Platforms

10:55 AM  Nathanael Gray | Extending the Reach of Kinase Inhibitor therapy using new targeting Strategies

11:05 AM  Jack Taunton | Chemoproteomic Map of Druggable Tyrosines and Lysines

11:15 AM  Lei Wang | New covalent bonding ability for proteins

11:25 AM  Charles Craik | Targeting an intracellular oncogene with immunotherapy against a haptenanted neoepitope

11:35 AM  Kevan Shokat | Expansion of Covalent Chemistry to Target the Undruggable Oncogenic Mutants of K-RAS

11:45 AM  15 min questions: https://pigeonhole.at/2627

12:00-1:15 PM: Lunch 

Session 3 - 1:15-2:20 PM: Engineered Sensors for Proteins, Cells and Animals | Chaired by: Michael Marletta

1:15 PM  Alanna Schepartz | Protein delivery

1:25 PM  Evan Miller | Fiat Lux: Fluorescent indicators to watch cellular physiology

1:35 PM  Xiaokun Shu | Functions of protein phase separation in chromatin structure and transcription

1:45 PM  Polly Fordyce | Microfluidics for high-throughput biochemistry and biophysics

1:55 PM  Matt Bogyo | Mapping proteases in the gut microbiome with small molecule probes

2:05 PM  15 min questions: https://pigeonhole.at/2627

2:20-2:45 PM: Coffee Break

Session 4 - 2:45-4:00 PM: Protein and Tissue Engineering | Chaired by: Alanna Schepartz

2:45 PM  Paul Carter | Probing the Molecular Basis of High Viscosity of Monospecific and Bispecific IgG Antibodies (tentative title)

2:55 PM  Matt Francis | Synthesis of Protein-Protein Conjugates Using Enzymatic Oxidative Coupling Reactions

3:05 PM  Zev Gartner | What is tissue structure good for?

3:15 PM  Bill Degrado | De Novo Protein Design

3:25 PM  Alice Ting | Protein engineering for immuno-oncology

3:35 PM  Peter Kim | Broad-spectrum protection and treatment of SARS-CoV-2

3:45 PM  15 min questions: https://pigeonhole.at/2627

4:00-4:45 PM: Industry Leaders (New Visions and Challenges for Pharma)

  Moderator: Jim Wells; Panelists: Andrew Chan, Ray Deshaies, Shiva Malek

4:45-5:00 PM: Closing remarks

5:00-6:00 PM: Poster Session

6:00-7:00 PM: Reception

Day 2 - September 27th

8:00 AM: Registration & Breakfast

9:00-9:10 AM: Symposium begins: Welcome speech by organizers 

Session 5 - 9:10-10:25 AM: Natural and Synthetic Small Molecules in Drug Discovery and Therapy | Chaired by: Peter Kim

9:10 AM  James Chen | Targeting colorectal cancer with small-molecule inhibitors of ALDH1B1

9:20 AM  Jason Sello | Illuminating Biology with Bioactive Small Molecules

9:30 AM  Wenjun Zhang | Bioactive natural product discovery and biosynthesis

9:40 AM  Ian Seiple | Chemical synthesis to unlock natural product potential

9:50 AM  Pam England | Developing Nurr1 Modulators for Treating Neurodegneration

10:00 AM John Link | Lenacapavir: A Twice-Yearly Dosed First-in-Class HIV Capsid Inhibitor

10:10 AM  15 min questions: https://pigeonhole.at/2627

10:25-10:40 AM: Break 

Session 6 - 10:40-11:45 AM: Chemical Microbiology and Immunology | Chaired by: Bill DeGrado

10:40 AM  Jaime Cate | Translating T cell biology

10:50 AM  Balyn Zaro | Bacterial Mimicry of Mammalian 'Don't Eat Me' Signals

11:00 AM  Allison Williams | Decoding bacterial host communication

11:10 AM  Misty Kuhn | Unraveling polyamine acetyltransferase allosteric networks

11:20 AM  Lingyin Li | Chemical biology of the innate immune STING pathway

11:30 AM  15 min questions: https://pigeonhole.at/2627

11:45-1:30 PM: Lunch

1:30-1:45 PM: Twitter Interview: Nobel Laureate, Jennifer Doudna on Gene Editing and the Future of CRISPR (Sponsored by Synthego)

Host: Jason Gestwicki; Guest: Jennifer Doudna

Session 7 - 1:45-2:50 PM: Intracellular Signaling | Chaired by: Chris Chang

1:45 PM  Eric Kool | RNA acylation as a universal tool for transcriptome studies

1:55 PM  Nicole Martinez | Uncovering new functions of the RNA modifications in mRNA processing

2:05 PM  Danica Fujimori | Proximity Reactive Cyclic Peptides as Covalent Probes for Epigenetic Proteins

2:15 PM  Natalia Jura | Mechanistic insights into signaling by protein kinases

2:25 PM  Jason Gestwicki | Protein-Protein Interactions at C-Termini Regulate Protein Stability

2:35 PM  15 min questions: https://pigeonhole.at/2627

2:50-4:00 PM: Poster Session with refreshments

4:00-4:45 PM: Entrepreneur Panel (Translating Commercial Reality)

  Moderator: Kevan Shokat; Panelists: Charles Homcy, Patrick Baeuerle, Arnon Rosenthal

4:45-5:00 PM: Closing remarks/(Top 3 Posters Announced)

5:00-7:00 PM: Final Reception and Celebration

COVID-19 PROTOCOLS:

UCSF employees/vendors/trainees need (all listed items):

• Negative Color/PCR test in previous 48 hours or negative antigen within 12 hours before the event.
• Proof of full vaccination booster (unless exempt)
• Completed Daily Health Screener

All non-UCSF guests/visitors need (all listed items):

• Negative rapid antigen test within 12 hours before the event
• Proof of full vaccination booster
• Completed Visitor/Guest Health Screener

Masks are not required but strongly recommended indoors

Event guidance is based on U.S. Centers for Disease Control and Prevention’s (CDC) Community Level Classification for campus event settings, and UCSF’s enterprise transmission risk levels. Learn more about UCSF Covid policies, guidelines and resources here.