HARC is a collaborative research center to study HIV Accessory and Regulatory Complexes.
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HARC Newsletter
The HARC Newsletter is here to nurture and strengthen our research community and covers an array of topics, offering valuable insights that allow us to learn from one another and grow together.
Research Highlight
The structural basis for HIV-1 Vif antagonism of human APOBEC3G. Li et al., February 2023
The APOBEC3 (A3) proteins are host antiviral cellular proteins that hypermutate the viral genome of diverse viral families. In retroviruses, this process requires A3 packaging into viral particles1-4. The lentiviruses encode a protein, Vif, that antagonizes A3 family members by targeting them for degradation.
Functional and structural segregation of overlapping helices in HIV-1. Safari et al., May 2022
Overlapping coding regions balance selective forces between multiple genes. One possible division of nucleotide sequence is that the predominant selective force on a particular nucleotide can be attributed to just one gene.
Collaborative Opportunities
HARC has funds to support up to 3 Collaborative Developmental Awards per year, to improve research on HIV-host protein complexes and expand treatment modalities for HIV/AIDS.