QBI - Symposium




1:00 PM-5:00 PM

The 2017 Cell Mapping Symposium, hosted by Nevan Krogan of The Quantitative Biosciences Institute (QBI) at UCSF, Trey Ideker of The Cancer Cell Map Initiative (CCMI) at UC San Diego and Jeremy Willsey of The Psychiatric Cell Map Initiative (PCMI) at UCSF will address research and technology advances in cell mapping as it relates to cancer, psychiatric disorders, and infectious diseases. The ability of a cell to respond to its environment depends on the actions of the proteins encoded by the DNA in the genome. However, most proteins don’t work alone. They work with other proteins in teams called complexes. The principles of “cell mapping” are to figure out which proteins work together in complexes. Mapping can be done in different disease states or in the presence of different chemical drugs. To accomplish these goals, researchers augment these cell maps with genetic maps to derive quantitative insights into how biological functions of cells can be restored.


Wednesday, September 13, 2017 

Welcome Speech: 1:00 PM 

Session 1: Cancer 1:20 PM – 3:00 PM (Chair: Ben Raphael, Princeton University)

1:20 PM Peter Jackson, Stanford University - "A KRAS physical and genetic interaction network reveals new cancer susceptibilities"

1:45 PM Martin Kampmann, UCSF - "Mapping neuronal cell biology in health and disease with CRISPRi and CRISPRa"

2:10 PM Joanna Loizou, Austrian Academy of Sciences -"Rebalancing DNA repair pathways in disease"

2:35 PM Dave Agard, UCSF - "Using Cryo-Em to understand dynamic protein complexes"

Coffee Break 3:00 PM

Session 2: Neurodevelopmental Disorders 3:20 PM – 5:00 PM (Session Chair: Jeremy Willsey, UCSF)

3:20 PM Jeremy Willsey, UCSF -"Identifying convergent molecular pathways in Autism"

3:45 PM Mark von Zastrow, UCSF - "Spatiotemporal dynamics of protein interaction networks in living cells"

4:10 PM Kevan Shokat, UCSF -"Chemical tricks for drugging the undruggable"

4:35 PM Cori Bargmann, Chan Zuckerberg Initiative & The Rockefeller University - “Diversity of cellular function in the nervous system”

DAY 2: Thursday, September 14, 2017 - Symposium Begins 9:30 AM

Session 3: Technology Development 9:30 AM – 11:10 AM (Session Chair: Andrej Sali, UCSF)

9:30 AM Rick Horwitz, Allen Institute - "Integrated spatial-temporal stem cell biology - a next step in the post genomic era"

9:55 AM Teresa Przytycka, NCBI-NIH -"New methods to uncover properties of mutational landscape in cancer"

10:20 AM - Andrej Sali, UCSF - "Integrative structural biology"

10:45 AM Ben Raphael, Princeton University - "Network Analysis of Cancer Genomes”

Lunch Break 11:10 AM – 12:45 PM 

Session 4: Infectious Diseases 12:45 PM – 2:25 PM (Session Chair: Nevan Krogan, UCSF)

12:45 PM Nevan Krogan, UCSF -"Using systems approaches to study infectious disease"

1:10 PM Clodagh O'Shea, Salk Institute - "Exploiting Viruses as a System to Understand and Treat Cancer"

1:35 PM Jeff Cox, UC Berkeley - "Using proteomics to probe the TB-host interface"

2:00 PM Kathryn Miller-Jensen, Yale University - " Identifying T cell signaling networks dysregulated by latent and reactivating HIV"

Coffee Break 2:25 PM

Session 5: Cancer 2:45 PM – 4:25 PM (Session Chair: Trey Ideker, UC San Diego)

2:45 PM Laura van ’t Veer, UCSF - "Mapping treatment response to biological networks: the I-SPY 2 TRIAL"

3:10 PM Jennifer Grandis, UCSF - "Targeting the PIK3CA mutant interactive in Head and Neck Cancer"

3:35 PM Michael Boutros, DKFZ - "Mapping genetic interaction networks (in cancer cells)"

4:00 PM Trey Ideker, UC San Diego -"Towards a structure/function simulation of a cancer cell"

4:25 PM Closing Remarks 

Cell Mapping Symposium

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