Co-organized by Drs. Davide Ruggero and Sourav Bandyopadhyay of UC San Francisco, the inaugural Quantitative Biology of the Cancer Cell Symposium will be held on campus at the University of California, San Francisco on February 24-25, 2020. Under the leadership of Dr. Nevan Krogan, the Quantitative Biosciences Institute (QBI) seeks transformative results in biomedicine by supporting fundamental quantitative research in the biological sciences. In support of this mission, the symposium will focus on cutting edge new quantitative experimental and computational approaches for understanding new facets of cancer biology as well as therapeutic interventions. The Cancer Cell Map Initiative (CCMI, ccmi.org), which was jointly formed by QBI and UC San Diego, aims to create molecular maps of the cancer cell.  The symposium is sponsored by Bruker. 

Agenda:

Day 1: February 24, 2020

9:30AM-10:50AM -Registration & Breakfast 

11:00 AM - Welcome speech by Nevan Krogan, Director of QBI at UCSF

Thematic Session One: Nucleus/Genome Instability

11:00 AM - Alejandro Sweet-Cordero - Genomic analysis of osteosarcoma: insights into tumor evolution and therapy response

11:30 AM- Stephen Taylor - Exploiting DNA replication vulnerabilities to target ovarian cancer

12:00 PM - Rapid Talk by Julia Rohrberg, UC San Francisco

12:15 PM-1:15 PM LUNCH

Thematic Session Two: RNA

1:15 PM Hani Goodarzi - Revealing the RNA structural code that governs regulatory RNA-protein interactions.

1:45 PM Reuven Agami - Amino acid vulnerabilities in cancer

2:15 PM Robert Schneider - Translational regulation of breast cancer metastasis and the mesenchymal transition

2:45 PM Maria Barna - Ribosomes in Gene Regulation: Controlling the diversity of proteins made in specific cells, tissues, & organisms

3:15 PM Christine Mayr - Regulation of protein functions by 3' UTRs

3:45 PM COFFEE BREAK

Thematic Session Three: Protein Homeostasis

4:00 PM Or Gozani - Lysine Methylation Signaling in Epigenetic and Cancer Regulation

4:30 PM Davide Ruggero - Decoding the cancer genome one codon at a time and its therapeutic implications

5:00 PM Rapid Talk by Ozlem Aksoy, UC San Francisco

5:15 PM Ruedi Aebersold - The modular proteome and its biological significance

5:45 PM Closing Remarks

Day 2: February 25, 2020

8:30 AM Registration

9:00 AM SYMPOSIUM BEGINS (Welcome Speech)

Thematic Session Four: Metabolism

9:00 AM Ralph Deberardinis - Metabolic phenotypes and liabilities in human cancer

9:30 AM Rushika Perera - New players and unique features of cancer lysosomes

10:00 AM Heather Christofk - Metabolic Transitions in Cancer

10:30 AM COFFEE BREAK

Thematic Session Five: Systems Biology of Therapy

10:45 AM Sourav Bandyopadhyay - Tyrosine kinase network mediated oncogenesis in lung cancer

11:15 AM Kris Wood - Systematic identification of therapeutic strategies that leverage tumor evolution

11:45AM-1:15PM Lunch

12:00PM-1:00PM **Lunch Seminar Sponsered by Bruker (at BH-121)

1:15 PM Thematic Session Five (Continued): Systems Biology of Therapy

1:15 PM Rafaella Sordella - Encoding and Decoding through receptor tyrosine kinase signaling

1:45 PM Angela Brooks - Transcriptome alterations associated with mutations in cancer genomes

2:15 PM Coffee Break

2:30 PM (KEYNOTE) Rene Bernards - Unconventional approaches to the treatment of cancer

3:00 PM Thematic Session Six: Emerging clinical and experimental approaches

3:00 PM Andrea Bild - Evolution of tumor and normal cells in breast cancer patients during treatment

3:30 PM Laura Van 't veer - I-SPY with my little eye your best-matched breast cancer treatment

4:00 PM Emma Lundberg - Spatiotemporal dissection of the human proteome

Confirmed Speakers:

Ruedi Aebersold, ETH Zurich

Reuven Agami, Netherlands Cancer Institute

Samuel Bakhoum, Memorial Sloan Kettering Cancer Center

Sourav Bandyopadhyay, University of California, San Francisco

Maria Barna, Stanford University

Rene Bernards, Netherlands Cancer Institute

Andrea Bild, City of Hope

Angela Brooks, UC Santa Cruz

Heather Christofk, University of California, Los Angeles

Ralph De Berardinis, University of Texas, Southwestern

Hani Goodzari, University of California, San Francisco

Or Gozani, Stanford University

Emma Lundberg, Stanford University

Christine Mayr, Memorial Sloan Kettering Cancer Center

Rushika Perera, University of California, San Francisco

Davide Ruggero, University of California, San Francisco

Robert Schneider, New York University

Rafaella Sordella, Cold Spring Harbor Laboratory

Stephen Taylor, University of Manchester

Laura van’t Veer, University of California, San Francisco

Kris Wood, Duke University