Please note that registrations received after October 28, 2026, will not include a pre-printed name badge.

Day One

8:00 AM – Doors Open/Registration (Atrium - 1st Floor)

OPENING SESSION (Auditorium - 2nd Floor)
9:00 AM – Opening Remarks by Nevan Krogan, UC San Francisco and Robyn Kaake, UC San Francisco

9:30 AM – Keynote Talk by Lan Huang, University of California Irvine – introduced by Robyn Kaake, UC San Francisco

10:30 AM – Sponsored Talk by Ryan Bomgarden, Thermo Fisher Scientific
"The Evolution of Protein Crosslinking: Simplifying Workflows for Complex Protein Samples"

10:40 AM – Break


SESSION ONE (Auditorium - 2nd Floor) – Cross-Linking Mass Spectrometry (Part I) – Chaired by Robyn Kaake, UC San Francisco
11:00 AM – James Bruce, University of Washington
“Cellular stress interactome dynamics”

11:20 AM – Leah McDermott, University of Washington
"Mapping the Mitochondrial Permeability Transition Pore Interactome to Reveal Mechanisms of Human Aging and Disease"

11:35 AM – Patrick Griffin, University of Florida
"Illuminating the functional components of NR transcriptional regulatory complexes"

11:55 AM – Changjian Feng, University of New Mexico
"Quantitative Cross-linking MS and Template-guided Structure Prediction Map Calmodulin-dependent Domain Rearrangements in Neuronal Nitric Oxide Synthase"

12:10 PM – Sponsored Lunch

1:25 PM – Platinum Sponsor Presentation (Auditorium - 2nd Floor) 

Weijing Liu, Thermo Fisher Scientific
"Structural Biology Mass Spectrometry: Bridging Proteoforms, Structure, and Interactions"

SESSION TWO (Auditorium - 2nd Floor) – HDX/Covalent Labeling – Chaired by Monita Muralidharan, UC San Francisco 
1:55 PM – Lisa Jones, UC San Diego

2:15 PM – Monika Priyadarshini, Stanford University
"Integrative Structural  Mapping of Chromatin Condensates by Phase-resolved HDX-MS and XLMS"

2:30 PM – Ben Walters, Genentech

2:50 PM – Petr Novak, Institute of Microbiology of the Czech Academy of Sciences
"Mapping Protein Structure with Singlet Oxygen Labeling"

3:05 PM – David Schriemer, University of Calgary
"An HX-MS² Technology Platform for Overcoming Performance Limitations in Hydrogen-deuterium Exchange"

3:25 PM – Break


SESSION THREE (Auditorium - 2nd Floor) – Native/Top Down – Chaired by Shouling Xu, UC San Francisco 
3:45 PM – Michal Sharon, Weizmann Institute of Science
"From Intact Proteoforms to Organ-Specific Aging Trajectories"

4:05 PM – Neil Kelleher, Northwestern University
"The Plasma Proteoform Assay: Tracking Progressive Liver Cirrhosis via >1500 Plasma Proteoforms across >200 Subjects"

4:25 PM – Corinne Lutomski, UC San Francisco

"Proteoforms in Context: Mapping Membrane Protein Interactions by Native Top-Down MS"

4:45 PM – Kallol Gupta, Yale University
"Resolving Dynamic Membrane Signaling Assemblies by Single-Ion Lipid-Vesicle Native MassSpectrometry"

5:00 PM – Ruben Luo, Stanford University
"Clinical Testing of Monoclonal and Oligoclonal Immunoglobulins Using Top-Down Mass Spectrometry"

5:20 PM – Poster Session with Light Reception

Day Two

8:00 AM – Doors Open/Registration (Atrium - 1st Floor)

SESSION FOUR (Auditorium - 2nd Floor) – Drug Discovery – Chaired by Nadia Arang, UC San Francisco 
9:00 AM – Malvina Papanastasiou, The Broad Institute
"Enabling Early-stage Drug Discovery with NanoHDX-MS: Rapidly Interrogating Protein-protein and Protein-small Molecule Interactions at Scale"

9:20 AM – Liz Hecht, Amgen

9:40 AM – Darragh O'Brien, University of Oxford
"HDX-MS Reveals the Structural Dynamics Underlying Drug Activity: Insights from Deubiquitinase Inhibitors"

10:00 AM – Break


SESSION FIVE (Auditorium - 2nd Floor) – CryoEM/CryoET – Chaired by Kliment Verba, UC San Francisco 
10:20 AM – Oleg Klykov, UT Health San Antonio
"Approaches for Physiologically Relevant Structural Proteomics"

10:35 AM – Michael Rout, Rockefeller University

10:55 AM – Mia Greeson, Stanford University
"Structural and Proteomic Sissection of GPR143 Defines a Non-canonical GPCR-effector Interface Underlying Ocular Albinism"

11:10 AM – Yifan Cheng, UC San Francisco

11:30 AM – Group Picture

12:00 PM – Sponsored Lunch

1:00 PM – Gold Sponsor Presentation 

Michael Greir, Bruker
"Bruker - Connecting Proteoform Identity, Molecular Structure and Dynamics to Changes in Biology"

1:20 PM – Gold Sponsor Presentation by Trajan Scientific

Bruno Amaral, University of Calgary
"Chemistry-defined Search Spaces for Whole-cell Crosslinking Mass Spectrometry"
 

SESSION SIX (Auditorium - 2nd Floor) – Computational Modeling – Chaired by Dominic Grisingher, UC San Francisco
1:40 PM – Andrej Sali, UC San Francisco

2:00 PM – Haiyuan Yu, Cornell University
"Interactome Scale Structural Modeling of Protein Interactions and Systematic Blindspots of AlphaFold"

2:15 PM – Roland Dunbrack, Fox Chase Cancer Center
"ipSAE: A PAE-based Confidence Metric for Protein Interactions with Other Proteins, Ligands, and Nucleic Acids"

2:35 PM – Ignacia Echeverria-Riesco, UC San Francisco
"Integrative Structure Modeling of SynGAP1 in the Context of the Postsynaptic Density"

2:50 PM – Dima Kozakov, University of Texas

3:10 PM – Jure Leskovec, Stanford University

3:30 PM – Break


SESSION SEVEN (Auditorium - 2nd Floor) – Protein Interactions – Chaired by Danielle Swaney, UC San Francisco
3:50 PM – Francis O'Reilly, St. Jude Children's Research Hospital

4:10 PM – Simon Butterworth, Massachusetts Institute of Technology
"Proteome-wide Crosslinking Mass Spectrometry Reveals Novel Components of Essential Complexes in Toxoplasma"

4:25 PM – Jennifer Geddes-McAlister, University of Guelph
"From Protein Interactions to Functional Targets: Mass Spectrometry Reveals New Mechanisms of Fungal Infection"

4:45 PM – Monita Muralidharan, UC San Francisco
"Structural and Functional Characterization of an LtgA–LtgD Peptidoglycan-remodeling Assembly in Neisseria Meningitidis"

5:00 PM – Michael Trnka, UC San Francisco 

5:30 PM – Gala Dinner