2:00 PM-3:00 PM
The QBI Seminar Series is presenting Alice Telesnitsky of the University of Michigan. Dr. Telesnitsky is a professor at the Department of Microbiology and Immunology and the PI for The Center for HIV-1 RNA Studies at the University of Michigan Medical School.
Date: January 17, 2019
Location: Gladstone Institutes, Mahley Auditorium (1650 Owens Street)
Talk title: Regulating HIV-1 RNA fates: the ends as a means
HIV-1 replication requires the generation of several functionally distinct RNAs from a single transcription unit. What specifies HIV-1 RNAs’ partitioning into their diverse roles remains incompletely understood, but includes differential inclusion of regulatory elements via alternate splicing and the adoption of alternate 5’ leader RNA structures. Recent work has shown that HIV-1’s use of alternate transcription start sites influences unspliced RNA structures and fate decisions. While testing RNA structure-based predictions for splicing regulation, we discovered that features that differentiate fate classes of HIV-1 RNAs include polyA tail length. Together, these studies suggest that HIV-1 transcription start site choice initiates a cascade of molecular events that dictate the fates of nascent HIV-1 RNAs.
Host: Nevan Krogan
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