QBI and the READY Center present a seminar with Daniel Paull, the Senior Vice President, Discovery and Platform Development at The New York Stem Cell Foundation.

Dr. Paull has overseen the development and growth of the NYSCF Global Stem Cell Array – an automated platform for creating and utilizing stem cells at a large scale. Leading teams of biologists, automation engineers, and software developers, he continues to improve and scale this technology, overseeing its application to collaborative projects across the research community. He also leads NYSCF’s efforts to combine automation, imaging, and artificial intelligence to detect disease features and discover new drugs.

Dr. Paull received his PhD in Ophthalmology and Cell Biology from University College London, England, and performed his postdoctoral work in the lab of Dr. Dieter Egli, where he undertook research in diabetes and somatic cell nuclear transfer. He was also instrumental in devising mitochondrial replacement therapy (MRT), an IVF life technique used to prevent the inheritance of mitochondrial diseases. This work is now in clinical trials in the UK.

Talk Title: Leveraging Automation and AI for Stem Cell-Based Disease Modeling

Cell biology is at an intersection where, to generate datasets capable of being applicable to tools such as machine learning, an increase in experimental scale is required. Over the past decade, Dr. Paull and his group have worked to develop and optimize a platform, the NYSCF Global Stem Cell Array, capable of deriving, gene editing, and differentiating induced pluripotent stem cells (iPSCs). This talk will focus on the development of this platform, its use in disease modeling and its application at the intersection of biology and AI.

 Host: Lee Spraggon