Kathy Giacomini, Nevan Krogan, Aldema Sas-Chen, Ron Shamir, Ehud Gazit, Noam Shomron, Michelle Arkin, Margaux Pinney, Vered Padler-Karavani, James Fraser, Ignacia Echeverria, Tamir Tuller, Marina Sirota, Martin Kupiec, Elhanan Borenstein, Nir Ben-Tal, Tanja Kortemme, Yoni Haitin, Nadav Ahituv, Rina Rosin-Arbesfeld, Ran Elkon, Brian Shoichet, Tzachi Hagai
Co-organized by Drs. Kathy Giacomini, Nevan Krogan, Aldema Sas-Chen, and Ron Shamir, the Quantitative Biosciences Institute (QBI) at the University of California, San Francisco, the Edmond J. Safra Center for Bioinformatics at Tel Aviv University (TAU), and the BLAVATNIC CENTER for Drug Discovery at TAU present the second QBI/UCSF-TAU Symposium on Computational Biology and Drug Discovery.
QBI seeks transformative results in biomedicine by supporting fundamental quantitative research in the biological sciences. The Edmond J. Safra Center for Bioinformatics promotes TAU as a leading force in the field of bioinformatics towards the development of novel drugs and biomedical technologies that will improve human health. The BLAVATNIK CENTER for Drug Discovery aims to turn excellent multidisciplinary science into therapeutics leads. The 2023 symposium aims to continue facilitating collaborative relationships between scientists from the participating institutions.
9:15 AM - Ehud Gazit, TAU | Professor & Endowed Chair, Molecular Microbiology and Biotechnology; Founding Director, BLAVATNIK CENTER for Drug Discovery
Peptide and metabolite self-assembly: Physiology, pathology and nanotechnology
9:30 AM - Kathy Giacomini, QBI/UCSF | Dean, School of Pharmacy; Co-Director UCSF-Stanford Center of Excellence in Regulatory Sciences and Innovation; Professor, Bioengineering and Therapeutic Sciences
The UCSF-Stanford Center of Excellence In Regulatory Science: Advancing Drug Discovery
9:45 AM - Noam Shomron, TAU | Professor, Cell and Developmental Biology
Applied Genomics: what DNA and RNA can tell us
10:00 AM - Michelle Arkin, QBI/UCSF | Professor, Pharmaceutical Chemistry; Co-Director, Small Molecule Discovery Center
Structure-guided design of covalent probes and drug leads for hard targets
10:35 AM - Margaux Pinney, QBI/UCSF | Assistant Researcher, Biochemistry and Biophysics; Sandler Faculty Fellow
Leveraging High-Throughput Microfluidic Technologies to Quantify Drug Resistance Landscapes
10:50 AM - Vered Padler-Karavani, TAU | Associate Professor, Cell Research and Immunology
Targeting the sweet spot of human diseases
11:05 AM - James Fraser, QBI/UCSF | Professor, Bioengineering
Drugging Macrodomains
11:20 AM - Ignacia Echeverria, QBI/UCSF | Assistant Professor, Cellular Molecular Pharmacology
Structure modeling of related protein complexes in multiple conformational or compositional states
12:00-1:30 PM - LUNCH
1:30 PM - Tamir Tuller, TAU | Professor, Bio-Medical Engineering; Director, Laboratory of Computational Systems and Synthetic Biology
Computational modelling of gene expression: intro and medical applications
1:45 PM - Marina Sirota, QBI/UCSF | Associate Professor, Pediatrics
Leveraging Molecular and Clinical Data for Drug Discovery in the Era of Precision Medicine
2:00 PM - Martin Kupiec, TAU | Professor, Molecular Microbiology and Biotechnology; President, Genetic Society of Israel
Systematic analysis of the mechanisms that maintain telomere length
2:15 PM - Elhanan Borenstein, TAU | Professor, School of Computer Science; Professor, Sackler Faculty of Medicine; Head, Edmond J. Safra Center for Bioinformatics
Studying the gut microbiome interaction with metabolites, diet, and drugs
2:50 PM - Nir Ben-Tal, TAU | Professor, Biochemistry Molecular Biology
Anti-influenza A virus drug discovery
3:05 PM - Tanja Kortemme, QBI/UCSF | Professor, Bioengineering
New conformations and functions of de novo designed proteins
3:20 PM - Yoni Haitin, TAU | Assistant Professor, Physiology Pharmacology
Structure-based identification of novel geranylgeranyl diphosphate synthase inhibitors for multiple myeloma treatment
3:35 PM - Ron Shamir, TAU | Sackler Professor; Bionformatics
Analysis of disease using multiomic data
3:50 PM - Closing Remarks
8:30 AM - Registration and Coffee
9:00 AM - Nadav Ahituv, QBI/UCSF | Professor, Bioengineering; Director, UCSF Institute for Human Genetics
Functional characterization and therapeutic targeting of gene regulatory elements
9:15 AM - Rina Rosin-Arbesfeld, TAU | Professor, Department of Clinical Microbiology and Immunology; Vice Dean, Faculty of Medicine
Novel therapeutic strategies for treating diseases caused by nonsense mutations
9:30 AM - Ran Elkon, TAU | Associate Professor, Human Molecular Genetics Biochemistry
Enhancing early detection of breast cancer using polygenic risk scores
9:45-10:10 AM - BREAK
10:10 AM - Brian Shoichet, QBI/UCSF | Professor, Pharmaceutical Chemistry
Following the Rabbit into Chemical Space
10:25 AM - Aldema Sas-Chen, TAU | Assistant Professor/Senior Lecturer, Biomedicine and Cancer Research
When the heat is on – turn up the AC(4C): roles for dynamic acetylation in thermostabilization of RNA
10:40 AM - Tzachi Hagai, TAU | Senior Lecturer, Molecular Cell Biology & Biotechnology
The Evolutionary Paradox of Host-Virus interactions
10:55 AM - Closing Remarks