The QBI & Gladstone Institutes Infectious Disease and Human Health Seminar Series presents Dr. Ya-Chi Ho, an Associate Professor of Microbial Pathogenesis and Medicine (Infectious Diseases) at the Yale University School of Medicine.

Dr. Ho identifies mechanisms of HIV persistence, characterizes HIV-induced immune dysfunction, and develops HIV cure strategies. She identified the first HIV proviral landscape (Cell 2013) and how the immune selection pressure shapes the intact and defective HIV-infected cells (Cell Host Microbe 2017). She identified HIV-to-host RNA splicing and HIV-driven aberrant cancer gene expression as a mechanism of the clonal expansion of HIV-infected cells (Science Translational Medicine 2020, JCI 2020). She explores CRISPR screen (JVI 2022), 3D chromatin interactions (Genome Research 2023), and single-cell multiomic approaches (Immunity 2022, Immunity 2023) and identifies HIV-host interactions at the chromatin, RNA, and cellular, and systemic levels. She is a Plenary Speaker of AIDS 2023 and an elected member of The American Society for Clinical Investigation 2023.

Talk Title: Single-cell Epigenetic, Transcriptional, and Protein Profiling of Latent and Active HIV-1 Reservoir

Host: Julie Frouard

Zoom link: https://ucsf.zoom.us/j/99271372316?pwd=TS9xVWNXR3hHMCs0S3gxcEdBdit3Zz09

Passcode: 836898