1:00 PM-5:00 PM
Co-organized by James Fraser and Nevan Krogan, we are pleased to invite you to the 2017 QBI (Quantitative Biosciences Institute) Symposia on Spring Mutations: how deep sequencing is changing protein science. It will be the first of a series of QBI symposia that will focus on cutting edge technologies that are revolutionizing biology. This meeting, being co-sponsored by QBI and the Convergence Zone at the Gladstone Institutes, will be held March 14-15, 2017, at the UCSF Campus at Mission Bay in San Francisco, California. The event will start at 12:00pm on March 14, 2017 at the Mahley Auditorium and end at 4pm March 15, 2017.
Tuesday, March 14, 2017
1:00pm James Fraser, UCSF - Welcome Speech -Selections under different chemical conditions: leveraging graduate students
1:05pm - Thematic Session # 1 FOUNDATIONAL TECHNOLOGY: chair (James Fraser)
1:20pm Doug Fowler, University of Washington/ Fred Hutchinson Cancer Research Center -Deep mutational scanning to interpret variants in human genomes
1:40pm Adam Abate, UCSF -Sequence function mapping of enzymes and membrane proteins with microfluidics
2:00pm Sri Kosuri, University of California, Los Angeles
2:20pm COFFEE BREAK Room A/B
2:40pm Thematic Session #2 EVOLUTION (chair:Tina Perica)
2:40pm Debora Marks, Harvard University - Post-evolutionary biology: mutation effects predicted from genomic sequences
3:00pm Dan Bolon, University of Massachusetts - Biochemical and evolutionary lessons from viewing protein fitness landscapes through a next-gen lens
3:20pm Kim Reynolds, University of Texas, Southwestern Medical Center - Evolutionary modularity
3:40pm Lianet Noda-Garcia, The Weizmann Institute - Systematic mapping of chance and necessity in protein sequence evolution
4:00pm COFFEE BREAK Room A/B
Thematic Session #3 POTPURRI (chair: Dan Bolon)
4:20pm LIGHTNING TALKS
4:40pm Seemay Chou, University of California, San Francisco- The bacterial cell wall: probing an ancient structure with modern tools
5:00pm Jesse Bloom, Fred Hutchinson Cancer Research Center - Statistical methods to assess the adequacy of deep mutational scanning experiments for describing actual natural selection on proteincoding genes
DAY 2: Wednesday, March 15, 2017
9:00am Thematic Session # 4 ENGINEERING and THERAPEUTICS (chair:Katie Pollard)
9:00am Martin Kampman, University of California, San Francisco - CRISPR-based functional genomics to elucidate therapeutic targets and protein-drug interactions
9:20am Jim Wells, University of California, San Francisco - PhaNGS: A first generation Protein seq
9:40am Christian Cunningham, University of California, San Francisco - Using Next Generation Sequencing to Engineer Protein-based Therapeutics
10:00am Dave Savage, UC Berkeley - Synthetic Biological Tools for Probing and Perturbing Cellular Physiology
10:20am COFFEE BREAK Room C/D
10:40am Thematic Session #5 ENZYMES AND OTHER SYSTEMS (chair: Martin Kampmann)
10:40am Polly Fordyce, Stanford University - Harnessing microfluidics for high-throughput, quantitative enzymology
11:00am Lea Starita, University of Washington -Multiplex assays for measuring variant effects
11:20am Phil Romero, University of Wisconsin-Madison- Dissecting protein function with microfluidicbased deep mutational scanning
11:40am Catherine Fox, University of Wisconsin-Madison - Using deep sequencing to define the structure and regulation of yeast DNA replication origins at high-resolution
1:00pm Thematic Session #6 TOWARDS UNIVERSAL LOOKUP TABLES (chair: James Fraser)
1:00pm Cory Johannessen, Broad Institute - Systematic mapping of mutant kinase function through saturation mutagenesi
1:20pm Tanja Kortemme, University of California, San Francisco - Mutational perturbation of a fundamental biological switch
1:40pm Amit Majithia, Broad Institute - Making sense of missense: Prospective functional characterization of disease relevant proteins
2:00pm Ren Sun, University of California, Los Angeles - Functional analyses of influenza virus genome at single nucleotide resolution: application in rational design of vaccine for broad protection.
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