The QBI Seminar Series is presents Lars Plate, an Assistant Professor of Chemistry and Biological Sciences and Cornelius Vanderbilt Dean’s Faculty Fellow at Vanderbilt University. A native of Germany, Lars Plate earned his BS at MIT working under JoAnne Stubbe. He completed his doctoral work at UC Berkeley in Molecular and Cell Biology in the group of Michael Marletta. He then performed postdoctoral work at the Scripps Research Institute in the labs of Jeff Kelly and Luke Wiseman. In 2017, he joined the Chemistry and Biological Sciences faculty at Vanderbilt University where his team studies the dynamics and coordination of protein interaction networks in diverse cellular processes.

The Plate research group focuses on profiling the timing and coordination of protein interaction networks by combining chemical biology approaches with quantitative affinity purification-mass spectrometry methods. They have applied these tools to understand the protein quality control defects that give rise to protein misfolding diseases, such as thyroglobulin-associated hypothyroidism and Cystic Fibrosis. Additionally, they investigate what proteostasis processes play critical roles during flavivirus and coronaviruses infection and how these insights can be leveraged for development of host-targeted antivirals.

Talk Title: Choreographed Cellular Origami: Understanding Dynamic Protein Interactions in Health and Disease

Host: Danielle Swaney