2:30 PM-6:00 PM
Day 1: November 13 - 2:30PM-6:00PM
Day 2: November 14 - 9:00AM-6:00PM
Day 3: November 15 - 9:00 AM-2:00PM
Co-organized by Drs. Jeremy Willsey, Hao Li, and Nevan Krogan, the inaugural Psychiatric Cell Map Initiative Symposium will be held at Gladstone Institutes (1650 Owens St., San Francisco, CA 94158) on November 13-15, 2019. The Psychiatric Cell Map Initiative (PCMI, pcmi.ucsf.edu) aims to bridge the gap between the genome and the clinic in the field of psychiatric disorder research. In support of this mission, the symposium will focus on current progress in translating advances in gene discovery to an understanding of the molecular underpinnings of neurodevelopmental disorders. We will also emphasize approaches spanning disorders with shared etiology and/or convergent biology. Ultimately, we strive to build a community of interdisciplinary researchers that will collaboratively drive the field forward, so we welcome attendance from any and all fields.
NOVEMBER 13, 2019 , DAY 1— Gladstone Institutes (1650 Owen St. San Francisco, CA 94158)
2:00 PM Registration
2:30 PM SYMPOSIUM BEGINS: Welcome Speech by Nevan Krogan
Thematic Session One: Psychiatric Genetics. Chair: Jeremy Willsey
3:00 PM Donna Werling: “Genetic and developmental effects on gene expression in the human brain”
3:30 PM Jeremy Willsey: “Recent advances in the genetics of Tourette Syndrome and Obsessive-Compulsive Disorder”
4:00 PM Dan Lowenstein: “Insights from the Genome on Network Dysfunction in Epilepsy”
4:30 PM Hao Li: “Deciphering the genetic determinants of complex human traits through integrative analysis of GWAS and molecular trait data”
5:00 PM Keynote talk: Matt State: "Charting a path forward after successful gene discovery in autism spectrum disorders”
5:45 PM Closing Remarks
6:00 PM Reception in Gladstone
NOVEMBER 14, 2019, DAY 2— Gladstone Institutes (1650 Owen St. San Francisco, CA 94158)
9:00 AM Opening Remarks by Jeremy Willsey
Thematic Session Two: Psychiatric Cell Map Initiative. Chair: David Agard
9:10 AM Ruth Huttenhain: "Mapping protein interaction networks connecting autism spectrum disorder risk genes"
9:40 AM Martin Kampmann: “Functional Genomics in iPSC-derived models to elucidate neurodevelopmental and neurodegenerative diseases”
10:10 AM Brin Rosenthal: “An integrative network landscape neuropsychiatric disorders uncover shared network traits and commonly dysregulated pathways”
10:40 AM Coffee Break
Thematic Session Two: Psychiatric Cell Map Initiative (continued). Chair: Mark von Zastrow
11:00 AM Tom Nowakowski: “Human Brain Development at Single-Cell Resolution”
11:30 AM Helen Willsey: “Identifying convergent biology underlying autism using frogs”
12:00 PM Lunch
Rapid Talks: Chair: Brian Shoichet
1:00 PM Serena M. Tamura: “Development of CRISPR activation to rescue SCN2A haploinsufficiency in autism spectrum disorder”
1:15 PM Yuxiao Xu: “Using frogs to understand the function of autism risk gene DYRK1A”
1:30 PM Maureen Pittman: “Predicting the alteration of 3D chromatin organization in congenital anomalies”
1:45 PM Christoph Kirst: “Mapping whole brain structure and activity at cellular resolution: iDISCO and ClearMap”
2:00 PM Lakshmi Subramanian: “Neurodevelopmental Origins of Human Focal Cortical Dysplasia”
2:15 PM Siavash Fazel Darbandi: “TBR1 Dosage is Essential for Cortical Neuronal Spine Maturation and Synaptogenesis”
2:30 PM Coffee Break
Thematic Session Three: 3D Models of Human Brain Development. Chairs: Nawei Sun, Fima Zaltsman
3:00 PM Anca Pasca: “Hypoxia leads to corticogenesis defects in a 3D human model for brain injury of prematurity”
3:30 PM Keynote Talk: Saul Kato: “Large scale organoid generation for brain disorder screening”
4:15 PM Closing Remarks
4:30 PM Poster Session and Reception: Byers Hall Atrium, 600 16th St, 2nd Floor
6:00 PM Adjourn
NOVEMBER 15, 2019 , DAY 3— Gladstone Institutes (1650 Owen St. San Francisco, CA 94158)
9:00 AM Opening Remarks
Thematic Session Four: Intersecting Initiatives. Chair: Steve Finkbeiner
9:10 AM Aimee Kao: “Lysosomes as the Molecular Bridge between Neurodevelopmental and Neurodegenerative Disorders”
9:40 AM Frank McCormick: "Ras proteins in psychiatric disorders and development”
10:10 AM Lennart Mucke: "Intriguing Links between Developmental and Degenerative Brain Disorders"
10:40 AM Coffee Break
Thematic Session Four: Intersecting Initiatives (continued). Chairs: Helen Willsey and Brin Rosenthal
11:10 AM Katie Pollard: "Genetic variation and the 3D genome"
11:40 AM Casey Gifford: "Identifying Complex Genetic Mechanisms Involved in Congenital Heart Disease"
12:10 PM Keynote Talk: Mustafa Khokha: "CHD genetics reveals an unexpected connection between pluripotency and electrical membrane potential"
12:55 PM Closing Remarks by Jeremy Willsey
2:00 PM Adjourn
Ruth Huttenhain, UC San Francisco
Martin Kampmann, UC San Francisco
Aimee Kao, UC San Francisco
Saul Kato, UC San Francisco
Mustafa Khokha, Yale University
Hao Li, UC San Francisco
Dan Lowenstein, UC San Francisco
Frank McCormick, UC San Francisco
Lennart Mucke, Gladstone Institutes, UC San Francisco
Tom Nowakowski, UC San Francisco
Anca Pasca, Stanford University
Katie Pollard, Gladstone Institutes, UC San Francisco
Sara Brin Rosenthal, UC San Diego
Matthew State, UC San Francisco
Donna Werling, UW-Madison
Helen Willsey, UC San Francisco
Jeremy Willsey, UC San Francisco
Call for abstracts:
As part of the symposium, we are hosting a poster session and reception on Thursday, November 14th from 4:30 pm to 6:00 pm in the Byers Hall Atrium 2nd floor. We encourage interested attendees at every academic level to submit a brief poster abstract (title author list 1 paragraph) to Ashley Clement (email@example.com) for consideration. Six submissions will be chosen for a “Rapid Talks” section on November 14th from 1:00 pm to 2:30 pm (12 mins 3 mins for questions per talk). We will select poster presentation slots from the remaining abstracts. In order to be considered for the Rapid Talks, please submit your abstracts by 5 pm PST Wednesday, November 6th. We will accept additional abstracts for poster presentations only until 5 pm PST Friday, November 8th.
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