Jim Wells, PhD, UCSF - "Probing and attaching the surface-ome in cancer"

Abstract: The cell surface proteome (surface-ome) is the primary hub for cells to communicate with the outside world. Oncogenes are known to cause huge changes in cells and we find this translates to significant remodeling of the surface-ome. We generate recombinant antibodies to detect and then attack these cells by toxifying the antibodies or recruiting immune cells to kill.